Product details
Procaine Hydrochloride
Product details
Procaine Hydrochloride Information
Factory Supply high quality Procaine Hydrochloride Pharmaceutical Procaine HCl CAS:51-05-8
Name: Benzoic acid, 4-amino-,2-(diethylamino)ethyl ester, hydrochloride
CAS No.: 51-05-8
Formula: C13H20N2O2.HCl
Molecular Weight: 272.81
Synonyms: Benzoicacid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochloride (9CI);Allocaine;Anadolor;Anesthesol;Atoxicocaine;Cetain;Diethylaminoethanol 4-aminobenzoate hydrochloride;Ethocain;Ethocaine;Geriocaine;Gerovital H3;Irocaine;Isocain;Jenacaine;Kerocaine;Medaject;Naucain;Naucaine;Procaine hydrochloride;
EINECS: 200-077-2
Melting Point: 155-156 °C(lit.)
Boiling Point: 373.6 °C at 760 mmHg
Flash Point: 179.8 °C
Solubility: soluble in water
Appearance: white crystalline powder
Hazard Symbols: ToxicT
Risk Codes: 25-43-36/37/38-23/24/25
Safety: 36/37/39-45-37/39-26
Transport Information: UN 2811 6.1/PG 3
Procaine Hydrochloride Descriptions:
1. Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically . It acts mainly by being a sodium channel blocker. Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
2. Procaine was first synthesized in 1905, shortly after amylocaine. It was created by the German chemist Alfred Einhorn who gave the chemical the trade name , from the Latin nov- (meaning new) and -caine, a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun.
3. Prior to the discovery of Stovaine and was the most commonly used local anesthetic Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this and spent many years touring dental schools to advise them not to use it.
Procaine Hydrochloride Applications:
1. Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine.
2. Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
3. Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically .
4. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.
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